TY - JOUR
T1 - Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women
T2 - The "coronary artery risk development in young adults" women's study
AU - Calderon-Margalit, R.
AU - Schwartz, S. M.
AU - Wellons, M. F.
AU - Lewis, C. E.
AU - Daviglus, M. L.
AU - Schreiner, P. J.
AU - Williams, O. D.
AU - Sternfeld, B.
AU - Carr, J. J.
AU - O'Leary, D. H.
AU - Sidney, S.
AU - Friedlander, Y.
AU - Siscovick, D. S.
N1 - Funding Information:
This work was supported by National Heart, Lung, and Blood Institute ( Grant R01-HL065611 and Contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, and N01-HC-48050 ) and National Institutes of Health Career Development Award 5-K23-HL087114 (to M.F.W.).
PY - 2010/9
Y1 - 2010/9
N2 - Context: The role of endogenous androgens and SHBG in the development of cardiovascular disease in young adult women is unclear. Objective: Our objective was to study the prospective association of serum androgens and SHBG with subclinical coronary and carotid disease among young to middle-aged women. Design and Setting: This was an ancillary study to the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort study with 20 yr of follow-up. Participants: Participants included 1629 women with measurements of serum testosterone and SHBG from yr 2, 10, or 16 and subclinical disease assessment at yr 20 (ages 37-52 yr). Main Outcome Measures: Coronary artery calcified plaques (CAC) and carotid artery intima-media thickness (IMT) were assessed at yr 20. The IMT measure incorporated the common carotid arteries, bifurcations, and internal carotid arteries. Results: SHBG (mean of yr 2, 10, and 16) was inversely associated with the presence of CAC (multivariable adjusted odds ratio for women with SHBG levels above the median = 0.59; 95% confidence interval = 0.40-0.87; P = 0.008). SHBG was also inversely associated with the highest quartile of carotid-IMT (odds ratio for women with SHBG levels in the highest quartile = 0.56; 95% confidence interval = 0.37-0.84; P for linear trend across quartiles = 0.005). No associations were observed for total or free testosterone with either CAC or IMT. Conclusion: SHBG levels were inversely associated with subclinical cardiovascular disease in young to middle-aged women. The extent to which low SHBG is a risk marker or has its own independent effects on atherosclerosis is yet to be determined.
AB - Context: The role of endogenous androgens and SHBG in the development of cardiovascular disease in young adult women is unclear. Objective: Our objective was to study the prospective association of serum androgens and SHBG with subclinical coronary and carotid disease among young to middle-aged women. Design and Setting: This was an ancillary study to the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort study with 20 yr of follow-up. Participants: Participants included 1629 women with measurements of serum testosterone and SHBG from yr 2, 10, or 16 and subclinical disease assessment at yr 20 (ages 37-52 yr). Main Outcome Measures: Coronary artery calcified plaques (CAC) and carotid artery intima-media thickness (IMT) were assessed at yr 20. The IMT measure incorporated the common carotid arteries, bifurcations, and internal carotid arteries. Results: SHBG (mean of yr 2, 10, and 16) was inversely associated with the presence of CAC (multivariable adjusted odds ratio for women with SHBG levels above the median = 0.59; 95% confidence interval = 0.40-0.87; P = 0.008). SHBG was also inversely associated with the highest quartile of carotid-IMT (odds ratio for women with SHBG levels in the highest quartile = 0.56; 95% confidence interval = 0.37-0.84; P for linear trend across quartiles = 0.005). No associations were observed for total or free testosterone with either CAC or IMT. Conclusion: SHBG levels were inversely associated with subclinical cardiovascular disease in young to middle-aged women. The extent to which low SHBG is a risk marker or has its own independent effects on atherosclerosis is yet to be determined.
UR - http://www.scopus.com/inward/record.url?scp=77956596784&partnerID=8YFLogxK
U2 - 10.1210/jc.2009-2643
DO - 10.1210/jc.2009-2643
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C2 - 20554712
AN - SCOPUS:77956596784
SN - 0021-972X
VL - 95
SP - 4424
EP - 4431
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -
