Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: The stomach as a bioreactor

Joseph Kanner*, Shlomit Gorelik, Sirota Roman, Ron Kohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Recent studies dramatically showed that the removal of circulating modified low-density lipoprotein (LDL) results in complete prevention of atherosclerosis. The gastrointestinal tract is constantly exposed to food, some of it containing oxidized compounds. Lipid oxidation in the stomach was demonstrated by ingesting heated red meat in rats. Red wine polyphenols added to the rats' meat diet prevented lipid peroxidation in the stomach and absorption of malondialdehyde (MDA) in rat plasma. In humans, postprandial plasma MDA levels rose by 3-fold after a meal of red meat cutlets. MDA derived from meat consumption caused postprandial plasma LDL modification in human. The levels of plasma MDA showed a 75% reduction by consumption of red wine polyphenols during the meat meal. Locating the main biological site of action of polyphenols in the stomach led to a revision in the understanding of how antioxidants work in vivo and may help to elucidate the mechanism involved in the protective effects of polyphenols in human health.

Original languageAmerican English
Pages (from-to)8790-8796
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number36
DOIs
StatePublished - 12 Sep 2012

Keywords

  • antioxidants
  • lipid oxidation
  • malondialdehyde
  • modified LDL
  • plasma
  • polyphenols
  • stomach

Fingerprint

Dive into the research topics of 'Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: The stomach as a bioreactor'. Together they form a unique fingerprint.

Cite this