Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell

Jean Mukherjee, Gabriel Nussbaum, Matthew D. Scharff, Arturo Casadevall*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

Two immunoglobulin M monoclonal antibodies (mAbs) derived from the same B cell recognize different epitopes on the capsular polysaccharide of the pathogenic yeast, Cryptococcus neoformans. Their respective epitopes are located in spatially distinct regions of the capsule. Passive administration of one mAb prolonged survival whereas the other mAb did not. The results indicate that specificity is an important determinant of antibody efficacy against C. neoformans and that somatic mutations occurring during the antibody response can affect the protective efficacy of antibodies to C. neoformans.

Original languageAmerican English
Pages (from-to)405-409
Number of pages5
JournalJournal of Experimental Medicine
Volume181
Issue number1
DOIs
StatePublished - 1 Jan 1995
Externally publishedYes

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