Protein and peptide parenteral controlled delivery

Rajendra Pawar, Alon Ben-Ari, Abraham J. Domb*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Protein and peptide delivery has been a challenge due to their limited stability during preparation of formulation, storage and in vitro and in vivo release. These biopolymers have traditionally been administered via intramuscular or subcutaneous routes. Recent efforts have been made to develop formulations for non-invasive routes of administration, including oral, intranasal, transdermal and transmucosal delivery. Despite these efforts, invasive delivery remains the main method of administering peptide and protein drugs. This review focuses on recent developments in injectable, polymeric controlled-release formulations, with an emphasis on hydrogels and particulate systems.

Original languageEnglish
Pages (from-to)1203-1212
Number of pages10
JournalExpert Opinion on Biological Therapy
Volume4
Issue number8
DOIs
StatePublished - Aug 2004

Keywords

  • Controlled-release
  • Injectable particles
  • Invasive delivery
  • Peptide delivery
  • Protein delivery

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