TY - JOUR
T1 - Protein and peptide parenteral controlled delivery
AU - Pawar, Rajendra
AU - Ben-Ari, Alon
AU - Domb, Abraham J.
PY - 2004/8
Y1 - 2004/8
N2 - Protein and peptide delivery has been a challenge due to their limited stability during preparation of formulation, storage and in vitro and in vivo release. These biopolymers have traditionally been administered via intramuscular or subcutaneous routes. Recent efforts have been made to develop formulations for non-invasive routes of administration, including oral, intranasal, transdermal and transmucosal delivery. Despite these efforts, invasive delivery remains the main method of administering peptide and protein drugs. This review focuses on recent developments in injectable, polymeric controlled-release formulations, with an emphasis on hydrogels and particulate systems.
AB - Protein and peptide delivery has been a challenge due to their limited stability during preparation of formulation, storage and in vitro and in vivo release. These biopolymers have traditionally been administered via intramuscular or subcutaneous routes. Recent efforts have been made to develop formulations for non-invasive routes of administration, including oral, intranasal, transdermal and transmucosal delivery. Despite these efforts, invasive delivery remains the main method of administering peptide and protein drugs. This review focuses on recent developments in injectable, polymeric controlled-release formulations, with an emphasis on hydrogels and particulate systems.
KW - Controlled-release
KW - Injectable particles
KW - Invasive delivery
KW - Peptide delivery
KW - Protein delivery
UR - http://www.scopus.com/inward/record.url?scp=3442879344&partnerID=8YFLogxK
U2 - 10.1517/14712598.4.8.1203
DO - 10.1517/14712598.4.8.1203
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C2 - 15268656
AN - SCOPUS:3442879344
SN - 1471-2598
VL - 4
SP - 1203
EP - 1212
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
IS - 8
ER -