Protein-protein interactions of ASPP2: An emerging therapeutic target

Anat Iosub-Amir, Assaf Friedler*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The pro-apoptotic ASPP2 protein plays a central role in regulating apoptosis in both p53-dependent and p53-independent pathways. It has become clear in recent years that ASPP2 plays also a role in other important cellular processes like senescence and regulating cell polarity. ASPP2 interacts with numerous proteins in order to exert its pro-apoptotic effect while some other proteins inhibit its pro-apoptotic activity. These interactions are emerging potential targets for activation or inhibition. Drugs that activate ASPP2 may not only induce apoptosis of cancer cells, but also affect other disease-related cellular pathways. Here we review the interactions of ASPP2 with its partner proteins and their potential targeting for drug development.

Original languageAmerican English
Pages (from-to)1435-1443
Number of pages9
Issue number10
StatePublished - 1 Oct 2014

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