Protein scaffold engineering towards tunable surface attachment

Arnon Heyman*, Izhar Medalsy, On Bet Or, Or Dgany, Maya Gottlieb, Danny Porath, Oded Shoseyov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Ringing the changes: A selective, controlled, and tunable attachment of proteins to a metal or to insulating surfaces is presented. A ring-shaped protein encapsulating SiO2-binding peptides (see picture: yellow) was engineered to expose multiple binding sites simply by changing solvent conditions, thereby creating a single monolayer without the need for surface modification. (Figure Presented)

Original languageAmerican English
Pages (from-to)9290-9294
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number49
StatePublished - 23 Nov 2009


  • Nanofabrication
  • Protein structures
  • SP1
  • Self-assembly
  • Surface attachment


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