Protein sequences encoded by the relA and the spoT genes of Escherichia coli are interrelated

S. Metzger, E. Sarubbi, G. Glaser, M. Cashel

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

RelA and spoT are designations for two unlinked Escherichia coli genes whose products function in the synthesis and degradation of guanosine 3',5'-bispyrophosphate during the stringent regulatory response to amino acid deprivation. The RelA Protein catalyzes an ATP:GTP 3'-pyrophosphoryl group transfer reaction, and the SpoT protein has a guanosine 3',5'-bispyrophosphate 3'-pyrophosphohydrolyase activity. Both genes have been sequenced recently; the relA gene produces an 84-kDa protein, and the spoT gene is deduced to encode a 79-kDa protein. We report here that the protein sequences of the relA and spoT genes are extensively interrelated.

Original languageEnglish
Pages (from-to)9122-9125
Number of pages4
JournalJournal of Biological Chemistry
Volume264
Issue number16
StatePublished - 1989

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