Protocol for phage matching, treatment, and monitoring for compassionate bacteriophage use in non-resolving infections

Hadil Onallah, Ortal Yerushalmy, Ron Braunstein, Sivan Alkalay-Oren, Amit Rimon, Daniel Gelman, Shunit Coppenhagen-Glazer, Ronen Hazan*, Ran Nir-Paz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Phage therapy has re-emerged as a promising treatment for non-resolving infections. Given the lack of approved phage treatments, there is a need to establish a compassionate use pipeline. Here, we present a protocol for phage matching, treatment, and monitoring for compassionate bacteriophage use in non-resolving infections. We describe steps for consultation and request implementation, evaluating and comparing different aspects of phage activity, and phage production. We then detail procedures for multidisciplinary meetings, ethics approvals, phage therapy, and follow-up. For complete details on the use and execution of this protocol, please refer to Onallah et al.1,2

Original languageAmerican English
Article number102949
JournalSTAR Protocols
Volume5
Issue number2
DOIs
StatePublished - 21 Jun 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors

Keywords

  • Clinical Protocol
  • Health Sciences
  • Microbiology

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