Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

I. Kviatkovski, L. Chernin, T. Yarnitzky, I. Frumin, N. Sobel, Y. Helman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.

Original languageAmerican English
Pages (from-to)3258-3261
Number of pages4
JournalChemical Communications
Volume51
Issue number15
DOIs
StatePublished - 21 Feb 2015

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

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