Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

I. Kviatkovski; L. Chernin; T. Yarnitzky; I. Frumin; N. Sobel; Y. Helman

doi:10.1039/c4cc10393a

Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

I. Kviatkovski
, L. Chernin
, T. Yarnitzky
, I. Frumin
, N. Sobel
, Y. Helman^*

^*Corresponding author for this work

Department of Plant Pathology and Microbiology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.

Original language	English
Pages (from-to)	3258-3261
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	15
DOIs	https://doi.org/10.1039/c4cc10393a
State	Published - 21 Feb 2015

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© The Royal Society of Chemistry 2015.

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abstract = "In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.",

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AU - Chernin, L.

AU - Yarnitzky, T.

AU - Frumin, I.

AU - Sobel, N.

AU - Helman, Y.

PY - 2015/2/21

Y1 - 2015/2/21

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AB - In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.

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Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

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