Quality Control in Mitochondria

Kobi J. Simpson-Lavy; Hagai Abeliovich

doi:10.1016/B978-0-12-405528-5.00004-3

Quality Control in Mitochondria

Kobi J. Simpson-Lavy^*, Hagai Abeliovich

^*Corresponding author for this work

Institute of Biochemistry, Food Science and Nutrition

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Mitochondria are essential components of the eukaryotic cell, containing the machinery for efficient ATP production by oxidative phosphorylation and other metabolic processes. However, a side effect of these reactions is the generation of reactive oxygen species (ROS), which are deleterious to the integrity and functioning of mitochondria and to the cells which harbor them. Fortunately, cells possess a number of mechanisms to counter ROS damage in mitochondria, including repair, bypass reactions, and the degradation of damaged proteins and organelles. This final process occurs by utilizing the autophagic machinery to target damaged mitochondria for vacuolar degradation, and is termed mitophagy. This review discusses different mechanisms of mitochondrial quality control in yeast cells, with an emphasis on mitophagy.

Original language	English
Title of host publication	Mitophagy
Publisher	Elsevier Inc.
Pages	85-101
Number of pages	17
Volume	4
ISBN (Electronic)	9780124055339
ISBN (Print)	9780124055285
DOIs	https://doi.org/10.1016/B978-0-12-405528-5.00004-3
State	Published - 25 Jul 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.

Keywords

Mitochondrial dynamics
Mitochondrial quality control
Mitophagy
Mitophagy research

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10.1016/B978-0-12-405528-5.00004-3

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AB - Mitochondria are essential components of the eukaryotic cell, containing the machinery for efficient ATP production by oxidative phosphorylation and other metabolic processes. However, a side effect of these reactions is the generation of reactive oxygen species (ROS), which are deleterious to the integrity and functioning of mitochondria and to the cells which harbor them. Fortunately, cells possess a number of mechanisms to counter ROS damage in mitochondria, including repair, bypass reactions, and the degradation of damaged proteins and organelles. This final process occurs by utilizing the autophagic machinery to target damaged mitochondria for vacuolar degradation, and is termed mitophagy. This review discusses different mechanisms of mitochondrial quality control in yeast cells, with an emphasis on mitophagy.

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Quality Control in Mitochondria

Abstract

Bibliographical note

Keywords

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