Quality Control in Mitochondria

Kobi J. Simpson-Lavy*, Hagai Abeliovich

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Mitochondria are essential components of the eukaryotic cell, containing the machinery for efficient ATP production by oxidative phosphorylation and other metabolic processes. However, a side effect of these reactions is the generation of reactive oxygen species (ROS), which are deleterious to the integrity and functioning of mitochondria and to the cells which harbor them. Fortunately, cells possess a number of mechanisms to counter ROS damage in mitochondria, including repair, bypass reactions, and the degradation of damaged proteins and organelles. This final process occurs by utilizing the autophagic machinery to target damaged mitochondria for vacuolar degradation, and is termed mitophagy. This review discusses different mechanisms of mitochondrial quality control in yeast cells, with an emphasis on mitophagy.

Original languageAmerican English
Title of host publicationMitophagy
PublisherElsevier Inc.
Pages85-101
Number of pages17
Volume4
ISBN (Electronic)9780124055339
ISBN (Print)9780124055285
DOIs
StatePublished - 25 Jul 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.

Keywords

  • Mitochondrial dynamics
  • Mitochondrial quality control
  • Mitophagy
  • Mitophagy research

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