Abstract
The mathematical formulation for the dynamics of growth reduction and/or killing under antibiotic treatments has a long history. Even before the extensive use of antibiotics, attempts to model the killing dynamics of biocides were made [1]. Here, we review relatively simple quantitative formulations of the two main modes of survival under antibiotics, resistance and tolerance, as well as their heterogeneity in bacterial populations. We focus on the two main types of heterogeneity that have been described: heteroresistance and antibiotic persistence, each linked to the variation in a different parameter of the antibiotic response dynamics. Finally, we review the effects on survival of combining resistance and tolerance mutations as well as on the mode and tempo of evolution under antibiotic treatments.
| Original language | American English |
|---|---|
| Pages (from-to) | 139-145 |
| Number of pages | 7 |
| Journal | Current Opinion in Microbiology |
| Volume | 64 |
| DOIs | |
| State | Published - Dec 2021 |
Bibliographical note
Funding Information:We thank Yoav Kaplan for comments. This work was supported by the Minerva Foundation , the Israel Science Foundation (grant No. 597/20 ).
Publisher Copyright:
© 2021 Elsevier Ltd
