Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity

Shady Farah; Oren Aviv; Natalia Laout; Stanislav Ratner; Nurit Beyth; Abraham J. Domb

doi:10.1016/j.colsurfb.2015.01.051

Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity

Shady Farah, Oren Aviv, Natalia Laout, Stanislav Ratner, Nurit Beyth, Abraham J. Domb^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Quaternary ammonium (QA) methacrylate monomers and polymers were synthesized from a N-alkylation of N,. N-diethylaminoethyl methacrylate (DEAEM) monomer. Linear copolymers, and for the first time reported crosslinked nanoparticles (NPs), based QA-PDEAEM were prepared by radical polymerization of the quaternized QA-DEAEM monomers with either methyl methacrylate (MMA) or a divinyl monomer.QA-PDEAEM NPs of 50-70nm were embedded in polyethylene vinyl acetate coating. QA-polymers with N-C₈ and N-C₁₈ alkyl chains and copolymers with methyl methacrylate were prepared at different molar ratios and examined for their antimicrobial effectiveness. These coatings exhibited strong antibacterial activity against four representative Gram-positive and Gram-negative bacteria.

Original language	English
Pages (from-to)	608-613
Number of pages	6
Journal	Colloids and Surfaces B: Biointerfaces
Volume	128
DOIs	https://doi.org/10.1016/j.colsurfb.2015.01.051
State	Published - 1 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

Antimicrobial nanoparticles
Antimicrobial surfaces
Diethylaminoethyl methacrylate
Quaternary ammonium (QA) polymers

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10.1016/j.colsurfb.2015.01.051

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abstract = "Quaternary ammonium (QA) methacrylate monomers and polymers were synthesized from a N-alkylation of N,. N-diethylaminoethyl methacrylate (DEAEM) monomer. Linear copolymers, and for the first time reported crosslinked nanoparticles (NPs), based QA-PDEAEM were prepared by radical polymerization of the quaternized QA-DEAEM monomers with either methyl methacrylate (MMA) or a divinyl monomer.QA-PDEAEM NPs of 50-70nm were embedded in polyethylene vinyl acetate coating. QA-polymers with N-C8 and N-C18 alkyl chains and copolymers with methyl methacrylate were prepared at different molar ratios and examined for their antimicrobial effectiveness. These coatings exhibited strong antibacterial activity against four representative Gram-positive and Gram-negative bacteria.",

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AU - Laout, Natalia

AU - Ratner, Stanislav

AU - Beyth, Nurit

AU - Domb, Abraham J.

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KW - Antimicrobial surfaces

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Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity

Abstract

Bibliographical note

Keywords

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