Quickly Manufactured, Drug Eluting, Calcium Phosphate Composite Coating

Midhun Ben Thomas; Noah Metoki; Ori Geuli; Orna Sharabani-Yosef; Tal Zada; Meital Reches; Daniel Mandler; Noam Eliaz

doi:10.1002/slct.201601954

Quickly Manufactured, Drug Eluting, Calcium Phosphate Composite Coating

Midhun Ben Thomas, Noah Metoki, Ori Geuli, Orna Sharabani-Yosef, Tal Zada, Meital Reches, Daniel Mandler^*, Noam Eliaz

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Calcium phosphate (CaP) ceramics have been prevalently used as coatings for implants because of their excellent osteoconductive and bioactive properties. Yet, bone regeneration procedures might have complications such as bacterial infection, local inflammation, bone destruction, and impaired bone healing. Here, we present a novel in situ electrodeposition of CaP with chitosan nanoparticles containing antibiotics. The deposition was shown to be fast and efficient. The deposited layer of octacalcium phosphate (OCP) and monotite contained a large amount of gentamicin, which was released gradually over a period of 15 days. These phases may be beneficial for bone growth, as OCP has higher solubility than the stoichiometric hydroxyapatite (HAp) and is commonly considered as a precursor to HAp, while monotite has even faster resorbability. In addition, both the cytotoxicity and biomineralization of the coating were studied, and the coating was proven to be non-cytotoxic and highly biomimetic.

Original language	American English
Pages (from-to)	753-758
Number of pages	6
Journal	ChemistrySelect
Volume	2
Issue number	2
DOIs	https://doi.org/10.1002/slct.201601954
State	Published - 13 Jan 2017

Bibliographical note

Funding Information:
M.B.T. and N.M. contributed equally to this work. This study was financially supported by a Kamin grant 52694–5 from the Israel Ministry of Economy. The partial support by the Focal Technology Area through. The authors thank Dr. Yuri Rosenberg and Dr. Larisa Burstein from the Wolfson Applied Materials Resegarch Centre at Tel-Aviv University for their XRD and XPS character- ization service, respectively. We thank also Mario Levinshtein for his technical assistance.

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

Calcium phosphate
Cytotoxicity
Drug eluting
Gentamicin
In situ deposition

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10.1002/slct.201601954

Cite this

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title = "Quickly Manufactured, Drug Eluting, Calcium Phosphate Composite Coating",

abstract = "Calcium phosphate (CaP) ceramics have been prevalently used as coatings for implants because of their excellent osteoconductive and bioactive properties. Yet, bone regeneration procedures might have complications such as bacterial infection, local inflammation, bone destruction, and impaired bone healing. Here, we present a novel in situ electrodeposition of CaP with chitosan nanoparticles containing antibiotics. The deposition was shown to be fast and efficient. The deposited layer of octacalcium phosphate (OCP) and monotite contained a large amount of gentamicin, which was released gradually over a period of 15 days. These phases may be beneficial for bone growth, as OCP has higher solubility than the stoichiometric hydroxyapatite (HAp) and is commonly considered as a precursor to HAp, while monotite has even faster resorbability. In addition, both the cytotoxicity and biomineralization of the coating were studied, and the coating was proven to be non-cytotoxic and highly biomimetic.",

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author = "Thomas, {Midhun Ben} and Noah Metoki and Ori Geuli and Orna Sharabani-Yosef and Tal Zada and Meital Reches and Daniel Mandler and Noam Eliaz",

note = "Funding Information: M.B.T. and N.M. contributed equally to this work. This study was financially supported by a Kamin grant 52694–5 from the Israel Ministry of Economy. The partial support by the Focal Technology Area through. The authors thank Dr. Yuri Rosenberg and Dr. Larisa Burstein from the Wolfson Applied Materials Resegarch Centre at Tel-Aviv University for their XRD and XPS character- ization service, respectively. We thank also Mario Levinshtein for his technical assistance. Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Thomas, Midhun Ben

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AU - Zada, Tal

AU - Reches, Meital

AU - Mandler, Daniel

AU - Eliaz, Noam

N1 - Funding Information: M.B.T. and N.M. contributed equally to this work. This study was financially supported by a Kamin grant 52694–5 from the Israel Ministry of Economy. The partial support by the Focal Technology Area through. The authors thank Dr. Yuri Rosenberg and Dr. Larisa Burstein from the Wolfson Applied Materials Resegarch Centre at Tel-Aviv University for their XRD and XPS character- ization service, respectively. We thank also Mario Levinshtein for his technical assistance. Publisher Copyright: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/1/13

Y1 - 2017/1/13

N2 - Calcium phosphate (CaP) ceramics have been prevalently used as coatings for implants because of their excellent osteoconductive and bioactive properties. Yet, bone regeneration procedures might have complications such as bacterial infection, local inflammation, bone destruction, and impaired bone healing. Here, we present a novel in situ electrodeposition of CaP with chitosan nanoparticles containing antibiotics. The deposition was shown to be fast and efficient. The deposited layer of octacalcium phosphate (OCP) and monotite contained a large amount of gentamicin, which was released gradually over a period of 15 days. These phases may be beneficial for bone growth, as OCP has higher solubility than the stoichiometric hydroxyapatite (HAp) and is commonly considered as a precursor to HAp, while monotite has even faster resorbability. In addition, both the cytotoxicity and biomineralization of the coating were studied, and the coating was proven to be non-cytotoxic and highly biomimetic.

AB - Calcium phosphate (CaP) ceramics have been prevalently used as coatings for implants because of their excellent osteoconductive and bioactive properties. Yet, bone regeneration procedures might have complications such as bacterial infection, local inflammation, bone destruction, and impaired bone healing. Here, we present a novel in situ electrodeposition of CaP with chitosan nanoparticles containing antibiotics. The deposition was shown to be fast and efficient. The deposited layer of octacalcium phosphate (OCP) and monotite contained a large amount of gentamicin, which was released gradually over a period of 15 days. These phases may be beneficial for bone growth, as OCP has higher solubility than the stoichiometric hydroxyapatite (HAp) and is commonly considered as a precursor to HAp, while monotite has even faster resorbability. In addition, both the cytotoxicity and biomineralization of the coating were studied, and the coating was proven to be non-cytotoxic and highly biomimetic.

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KW - Gentamicin

KW - In situ deposition

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Quickly Manufactured, Drug Eluting, Calcium Phosphate Composite Coating

Abstract

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Keywords

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