Quickly Manufactured, Drug Eluting, Calcium Phosphate Composite Coating

Midhun Ben Thomas, Noah Metoki, Ori Geuli, Orna Sharabani-Yosef, Tal Zada, Meital Reches, Daniel Mandler*, Noam Eliaz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Calcium phosphate (CaP) ceramics have been prevalently used as coatings for implants because of their excellent osteoconductive and bioactive properties. Yet, bone regeneration procedures might have complications such as bacterial infection, local inflammation, bone destruction, and impaired bone healing. Here, we present a novel in situ electrodeposition of CaP with chitosan nanoparticles containing antibiotics. The deposition was shown to be fast and efficient. The deposited layer of octacalcium phosphate (OCP) and monotite contained a large amount of gentamicin, which was released gradually over a period of 15 days. These phases may be beneficial for bone growth, as OCP has higher solubility than the stoichiometric hydroxyapatite (HAp) and is commonly considered as a precursor to HAp, while monotite has even faster resorbability. In addition, both the cytotoxicity and biomineralization of the coating were studied, and the coating was proven to be non-cytotoxic and highly biomimetic.

Original languageAmerican English
Pages (from-to)753-758
Number of pages6
JournalChemistrySelect
Volume2
Issue number2
DOIs
StatePublished - 13 Jan 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • Calcium phosphate
  • Cytotoxicity
  • Drug eluting
  • Gentamicin
  • In situ deposition

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