Random nylon-3 copolymers: Synthetic polymers as host defense peptide mimics

S Chakraborty, RH Liu, Z Hayouka, J Ehrhardt, B Weisblum, SH Gellman

Research output: Contribution to journalMeeting Abstractpeer-review


Stereo- and sequence-random nylon-3 copolymers (poly-�-peptides) display exciting biological functions that might be of therapeutic interest, such as antimicrobial activity. The efficient and inexpensive preparation of these polymers and their intrinsic backbone similarity to conventional peptides/proteins makes the nylon-3 class attractive for biomedical applications.Cationic-lipophilic nylon-3 copolymers are proposed to adopt globally amphiphilic but irregular conformations upon approaching a biomembrane, which causes interactions with the lipid bilayer that degrade its barrier function and ultimately inhibit microbial growth. Our findings suggest that sequence-random nylon-3 copolymers containing both lipophilic and cationic subunits can display prokaryote vs. eukaryote selectivity patterns similar to those of sequence-controlled host defense peptides.

Original languageAmerican English
Number of pages1
JournalACS National Meeting Book of Abstracts
StatePublished - 16 Mar 2014

Bibliographical note

247th National Spring Meeting of the American-Chemical-Society (ACS), Dallas, TX, Meeting abstract 251-POLY


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