TY - JOUR
T1 - Rapid gas chromatographic assay for monitoring valproic acid and valpromide in plasma
AU - Bialer, Meir
AU - Friedman, Michael
AU - Rubinstein, Abraham
PY - 1984/7
Y1 - 1984/7
N2 - A gas chromatographic (GC) method for monitoring valproic acid and valpromide in plasma was developed. The procedure involved a single solvent extraction of drugs from acidified plasma samples, followed by a GC injection of the organic phase. This rapid, sensitive, specific, and reproducible method is a key factor in pharmacokinetic and stability studies of valpromide. Pharmacokinetic application of the new GC method is presented by a simultaneous plasma monitoring of valpromide and valproic acid levels obtained after intravenous administration of valpromide to a dog.
AB - A gas chromatographic (GC) method for monitoring valproic acid and valpromide in plasma was developed. The procedure involved a single solvent extraction of drugs from acidified plasma samples, followed by a GC injection of the organic phase. This rapid, sensitive, specific, and reproducible method is a key factor in pharmacokinetic and stability studies of valpromide. Pharmacokinetic application of the new GC method is presented by a simultaneous plasma monitoring of valpromide and valproic acid levels obtained after intravenous administration of valpromide to a dog.
KW - Valproic acid—GC, plasma, valpromide
KW - Valpromide—GC, plasma, valproic acid
UR - http://www.scopus.com/inward/record.url?scp=0021270970&partnerID=8YFLogxK
U2 - 10.1002/jps.2600730734
DO - 10.1002/jps.2600730734
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C2 - 6432998
AN - SCOPUS:0021270970
SN - 0022-3549
VL - 73
SP - 991
EP - 993
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 7
ER -