Abstract
A gas chromatographic (GC) method for monitoring valproic acid and valpromide in plasma was developed. The procedure involved a single solvent extraction of drugs from acidified plasma samples, followed by a GC injection of the organic phase. This rapid, sensitive, specific, and reproducible method is a key factor in pharmacokinetic and stability studies of valpromide. Pharmacokinetic application of the new GC method is presented by a simultaneous plasma monitoring of valpromide and valproic acid levels obtained after intravenous administration of valpromide to a dog.
| Original language | English |
|---|---|
| Pages (from-to) | 991-993 |
| Number of pages | 3 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 73 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1984 |
Keywords
- Valproic acid—GC, plasma, valpromide
- Valpromide—GC, plasma, valproic acid
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