TY - JOUR
T1 - Rapid test for fecal calprotectin levels in children with Crohn disease
AU - Kolho, K. L.
AU - Turner, D.
AU - Veereman-Wauters, G.
AU - Sladek, M.
AU - De Ridder, L.
AU - Shaoul, R.
AU - Paerregaard, A.
AU - Dias, J. Amil
AU - Koletzko, S.
AU - Nuti, F.
AU - Bujanover, Y.
AU - Staiano, A.
AU - Bochenek, K.
AU - Finnby, L.
AU - Levine, A.
AU - Veres, G.
PY - 2012/10
Y1 - 2012/10
N2 - Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95-0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100μg/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined.
AB - Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95-0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100μg/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined.
KW - Fecal biomarkers
KW - Inflammatory bowel disease
KW - Pediatric
UR - http://www.scopus.com/inward/record.url?scp=84866972564&partnerID=8YFLogxK
U2 - 10.1097/MPG.0b013e318253cff1
DO - 10.1097/MPG.0b013e318253cff1
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 22411269
AN - SCOPUS:84866972564
SN - 0277-2116
VL - 55
SP - 436
EP - 439
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 4
ER -