TY - JOUR
T1 - RAT UTERUS RENIN‐LIKE ACTIVITY
T2 - EFFECT OF STIMULI AND HORMONES
AU - GUTMAN, Y.
AU - MAZUR‐RUDER, M.
PY - 1976/3
Y1 - 1976/3
N2 - The characteristics of renin‐like activity in rat uterus were studied. The optimum temperature was 50°C and optimum pH 4.0. Potassium (100 mM) enhanced this activity but sodium or calcium had no effect. Uterine renin‐like activity was unchanged 24 h after bilateral nephrectomy. Renin‐like activity in the uterus increased slowly from birth to 4 weeks of age and faster between the 4th and 8th week. Ovariectomy caused a considerable fall in uterine renin‐like activity. The following factors, known to affect renin secretion in the kidney, i.e., hypovolaemia, sodium loading, adrenalectomy, administration of desoxycorticosterone acetate and injection of isoprenaline, had no effect on uterine renin‐like activity. Stilboestrol, an oestrogen, caused a significant increase of uterine renin‐like activity. Progesterone and testosterone had no significant effect on this activity but blocked the increase caused by stilboestrol. During pregnancy there was a small but significant fall of renin‐like activity in the uterus in the first week and a continuous increase throughout the later period of pregnancy. It is concluded that uterine renin‐like activity is independent of kidney renin and does not respond to stimuli affecting kidney renin. Uterine renin activity is hormone‐dependent and may be governed by the ratio, oestrogen: progesterone. 1976 British Pharmacological Society
AB - The characteristics of renin‐like activity in rat uterus were studied. The optimum temperature was 50°C and optimum pH 4.0. Potassium (100 mM) enhanced this activity but sodium or calcium had no effect. Uterine renin‐like activity was unchanged 24 h after bilateral nephrectomy. Renin‐like activity in the uterus increased slowly from birth to 4 weeks of age and faster between the 4th and 8th week. Ovariectomy caused a considerable fall in uterine renin‐like activity. The following factors, known to affect renin secretion in the kidney, i.e., hypovolaemia, sodium loading, adrenalectomy, administration of desoxycorticosterone acetate and injection of isoprenaline, had no effect on uterine renin‐like activity. Stilboestrol, an oestrogen, caused a significant increase of uterine renin‐like activity. Progesterone and testosterone had no significant effect on this activity but blocked the increase caused by stilboestrol. During pregnancy there was a small but significant fall of renin‐like activity in the uterus in the first week and a continuous increase throughout the later period of pregnancy. It is concluded that uterine renin‐like activity is independent of kidney renin and does not respond to stimuli affecting kidney renin. Uterine renin activity is hormone‐dependent and may be governed by the ratio, oestrogen: progesterone. 1976 British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0017074452&partnerID=8YFLogxK
U2 - 10.1111/j.1476-5381.1976.tb07640.x
DO - 10.1111/j.1476-5381.1976.tb07640.x
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C2 - 1260172
AN - SCOPUS:0017074452
SN - 0007-1188
VL - 56
SP - 285
EP - 292
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 3
ER -