Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule: The HIV-1 CD4:gp120 paradigm

Mattan Hurevich*, Avi Swed, Salim Joubran, Shira Cohen, Noam S. Freeman, Elena Britan-Rosich, Laurence Briant-Longuet, Martine Bardy, Christian Devaux, Moshe Kotler, Amnon Hoffman, Chaim Gilon

*Corresponding author for this work

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Keyphrases

Pharmacology, Toxicology and Pharmaceutical Science

Chemistry