RBC adhesion to vascular endothelial cells: More potent than RBC aggregation in inducing circulatory disorders

Saul Yedgar*, Dhananjay K. Kaul, Gregory Barshtein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Growing evidence has suggested that the adhesion of red blood cells (RBCs) to blood vessel wall endothelial cells (ECs) is a potent catalyst of microcirculatory disorders, but direct in vivo documentation has been lacking. In a recent study we have demonstrated the elevation of vascular resistance by RBCs with increased adhesion to ECs and normal deformability in the absence of aggregation. Unlike the previous chapter (i.e., the "point"), the findings and considerations discussed in this chapter (the "counterpoint) imply that RBC/EC adhesion is a more potent determinant of circulatory disorders than RBC aggregation.

Original languageAmerican English
Pages (from-to)581-583
Number of pages3
JournalMicrocirculation
Volume15
Issue number7
DOIs
StatePublished - 2008

Keywords

  • Circulatory disorders
  • Erythrocyte adhesion
  • Erythrocyte rheology

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