Ready, set, cleave: Proteases in action

Seth J. Salpeter, Galia Blum*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


Activity-based probes are small molecules that can be used to monitor enzyme activity by covalently binding to specific residues in the active site. In this issue of Chemistry & Biology, Lu and colleagues developed a specific fluorescent activity-based probe that targets the papain-like cysteine bacterial type III effector protease AvrPphB and used it to demonstrate the regulation of the protease secretion and pathogenesis.

Original languageAmerican English
Pages (from-to)137-138
Number of pages2
JournalChemistry and Biology
Issue number2
StatePublished - 21 Feb 2013


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