Real-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography

Noam Badt, Ori Katz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Fiber-based micro-endoscopes are a critically important tool for minimally-invasive deep-tissue imaging. However, current micro-endoscopes cannot perform three-dimensional imaging through dynamically-bent fibers without the use of bulky optical elements such as lenses and scanners at the distal end, increasing the footprint and tissue-damage. Great efforts have been invested in developing approaches that avoid distal bulky optical elements. However, the fundamental barrier of dynamic optical wavefront-distortions in propagation through flexible fibers limits current approaches to nearly-static or non-flexible fibers. Here, we present an approach that allows holographic, bend-insensitive, coherence-gated, micro-endoscopic imaging using commercially available multi-core fibers (MCFs). We achieve this by adding a partially-reflecting mirror to the distal fiber-tip, allowing to perform low-coherence full-field phase-shifting holography. We demonstrate widefield diffraction-limited reflection imaging of amplitude and phase targets through dynamically bent fibers at video-rate. Our approach holds potential for label-free investigations of dynamic samples.

Original languageAmerican English
Article number6055
JournalNature Communications
Issue number1
StatePublished - Dec 2022

Bibliographical note

Funding Information:
This work received funding from the European Research Council (ERC) Horizon 2020 research and innovation program (grants no. 677909, 101002406, OK), Azrieli foundation, Israel Science Foundation (1361/18, OK), Israeli Ministry of Science and Technology (Grant 712845, OK). We thank the Hebrew University Center for Nanoscience and Nanotechnology for distal mirror fabrication, and Tali Brooks for proofreading the manuscript.

Publisher Copyright:
© 2022, The Author(s).


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