Recent advances in nanomaterials for dermal and transdermal applications

Amani Zoabi, Elka Touitou*, Katherine Margulis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The stratum corneum, the most superficial layer of the skin, protects the body against environmental hazards and presents a highly selective barrier for the passage of drugs and cosmetic products deeper into the skin and across the skin. Nanomaterials can effectively increase the permeation of active molecules across the stratum corneum and enable their penetration into deeper skin layers, often by interacting with the skin and creating the distinct sites with elevated local concentration, acting as reservoirs. The flux of the molecules from these reservoirs can be either limited to the underlying skin layers (for topical drug and cosmeceutical delivery) or extended across all the sublayers of the epidermis to the blood vessels of the dermis (for transdermal delivery). The type of the nanocarrier and the physicochemical nature of the active substance are among the factors that determine the final skin permeation pattern and the stability of the penetrant in the cutaneous environment. The most widely employed types of nanomaterials for dermal and transdermal applications include solid lipid nanoparticles, nanovesicular carriers, microemulsions, nanoemulsions, and polymeric nanoparticles. The recent advances in the area of nanomaterialassisted dermal and transdermal delivery are highlighted in this review.

Original languageAmerican English
Article number18
JournalColloids and Interfaces
Issue number1
StatePublished - 18 Mar 2021

Bibliographical note

Publisher Copyright:
© 2020 by the authors.


  • Cosmeceuticals
  • Dermal delivery
  • Ethosome
  • Lipid nanocarriers
  • Liposome
  • Microemulsion
  • Nanocapsules
  • Nanoemulsion
  • Nanospheres
  • Permeation
  • Skin care
  • Transdermal delivery
  • Transfersome


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