Recent advances in phlebotomine sand fly research related to leishmaniasis control

Paul A. Bates, Jerôme Depaquit, Eunice Ab Galati, Shaden Kamhawi, Michele Maroli, Mary Ann McDowell, Albert Picado, Paul D. Ready*, O. Daniel Salomón, Jeffrey J. Shaw, Yara M. Traub-Csekö, Alon Warburg

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations

Abstract

Phlebotomine sand flies are the subject of much research because of the role of their females as the only proven natural vectors of Leishmania species, the parasitic protozoans that are the causative agents of the neglected tropical disease leishmaniasis. Activity in this field was highlighted by the eighth International Symposium on Phlebotomine Sand flies (ISOPS) held in September 2014, which prompted this review focusing on vector control. Topics reviewed include: Taxonomy and phylogenetics, Vector competence, Genetics, genomics and transcriptomics, Eco-epidemiology, and Vector control. Research on sand flies as leishmaniasis vectors has revealed a diverse array of zoonotic and anthroponotic transmission cycles, mostly in subtropical and tropical regions of Africa, Asia and Latin America, but also in Mediterranean Europe. The challenge is to progress beyond descriptive eco-epidemiology, in order to separate vectors of biomedical importance from the sand fly species that are competent vectors but lack the vectorial capacity to cause much human disease. Transmission modelling is required to identify the vectors that are a public health priority, the ones that must be controlled as part of the integrated control of leishmaniasis. Effective modelling of transmission will require the use of entomological indices more precise than those usually reported in the leishmaniasis literature.

Original languageAmerican English
Article number131
JournalParasites and Vectors
Volume8
Issue number1
DOIs
StatePublished - 27 Feb 2015

Bibliographical note

Publisher Copyright:
© 2015 Bates et al. licensee BioMed Central.

Keywords

  • Human leishmaniasis
  • ISOPS
  • Leishmaniasis control
  • Phlebotomine sand flies
  • Vector control

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