Recent Evolutionary History of Tigers Highlights Contrasting Roles of Genetic Drift and Selection

Ellie E. Armstrong*, Anubhab Khan, Ryan W. Taylor, Alexandre Gouy, Gili Greenbaum, Alexandre Thiéry, Jonathan T. Kang, Sergio A. Redondo, Stefan Prost, Gregory Barsh, Christopher Kaelin, Sameer Phalke, Anup Chugani, Martin Gilbert, Dale Miquelle, Arun Zachariah, Udayan Borthakur, Anuradha Reddy, Edward Louis, Oliver A. RyderYadvendradev V. Jhala, Dmitri Petrov, Laurent Excoffier, Elizabeth Hadly, Uma Ramakrishnan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Species conservation can be improved by knowledge of evolutionary and genetic history. Tigers are among the most charismatic of endangered species and garner significant conservation attention. However, their evolutionary history and genomic variation remain poorly known, especially for Indian tigers. With 70% of the world's wild tigers living in India, such knowledge is critical. We re-sequenced 65 individual tiger genomes representing most extant subspecies with a specific focus on tigers from India. As suggested by earlier studies, we found strong genetic differentiation between the putative tiger subspecies. Despite high total genomic diversity in India, individual tigers host longer runs of homozygosity, potentially suggesting recent inbreeding or founding events, possibly due to small and fragmented protected areas. We suggest the impacts of ongoing connectivity loss on inbreeding and persistence of Indian tigers be closely monitored. Surprisingly, demographic models suggest recent divergence (within the last 20,000 years) between subspecies and strong population bottlenecks. Amur tiger genomes revealed the strongest signals of selection related to metabolic adaptation to cold, whereas Sumatran tigers show evidence of weak selection for genes involved in body size regulation. We recommend detailed investigation of local adaptation in Amur and Sumatran tigers prior to initiating genetic rescue.

Original languageAmerican English
Pages (from-to)2366-2379
Number of pages14
JournalMolecular Biology and Evolution
Volume38
Issue number6
DOIs
StatePublished - 1 Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Keywords

  • carnivores
  • conservation genomics
  • population decline

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