Recently synthesized class of vinylphosphonates as potent matrix metalloproteinase (MMP-2) inhibitors

Abed Al Aziz Al-Quntar, Ofir Baum, Reuven Reich, Morris Srebnik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

An in vitro evaluation of MMP-2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalArchiv der Pharmazie
Volume337
Issue number2
DOIs
StatePublished - Feb 2004

Keywords

  • Cancer
  • Matrix Metallo-Proteinase
  • Phosphonates
  • Structure-activity relationships
  • Vinylphosphonates

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