Recently synthesized class of vinylphosphonates as potent matrix metalloproteinase (MMP-2) inhibitors

Abed Al Aziz Al-Quntar; Ofir Baum; Reuven Reich; Morris Srebnik

doi:10.1002/ardp.200300828

Recently synthesized class of vinylphosphonates as potent matrix metalloproteinase (MMP-2) inhibitors

Abed Al Aziz Al-Quntar
, Ofir Baum
, Reuven Reich
, Morris Srebnik^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

An in vitro evaluation of MMP-2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.

Original language	English
Pages (from-to)	76-80
Number of pages	5
Journal	Archiv der Pharmazie
Volume	337
Issue number	2
DOIs	https://doi.org/10.1002/ardp.200300828
State	Published - Feb 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Matrix Metallo-Proteinase
Phosphonates
Structure-activity relationships
Vinylphosphonates

Access to Document

10.1002/ardp.200300828

Cite this

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title = "Recently synthesized class of vinylphosphonates as potent matrix metalloproteinase (MMP-2) inhibitors",

abstract = "An in vitro evaluation of MMP-2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.",

keywords = "Cancer, Matrix Metallo-Proteinase, Phosphonates, Structure-activity relationships, Vinylphosphonates",

author = "Al-Quntar, \{Abed Al Aziz\} and Ofir Baum and Reuven Reich and Morris Srebnik",

year = "2004",

month = feb,

doi = "10.1002/ardp.200300828",

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issn = "0365-6233",

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AU - Al-Quntar, Abed Al Aziz

AU - Baum, Ofir

AU - Reich, Reuven

AU - Srebnik, Morris

PY - 2004/2

Y1 - 2004/2

N2 - An in vitro evaluation of MMP-2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.

AB - An in vitro evaluation of MMP-2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.

KW - Cancer

KW - Matrix Metallo-Proteinase

KW - Phosphonates

KW - Structure-activity relationships

KW - Vinylphosphonates

UR - https://www.scopus.com/pages/publications/1642388464

U2 - 10.1002/ardp.200300828

DO - 10.1002/ardp.200300828

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C2 - 14981663

AN - SCOPUS:1642388464

SN - 0365-6233

VL - 337

SP - 76

EP - 80

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

IS - 2

ER -

Recently synthesized class of vinylphosphonates as potent matrix metalloproteinase (MMP-2) inhibitors

Abstract

UN SDGs

Keywords

Access to Document

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