TY - JOUR
T1 - Reconstituted viral envelopes- 'Trojan Horses' for drug delivery and gene therapy?
AU - Blumenthal, Robert
AU - Loyter, Abraham
PY - 1991/1
Y1 - 1991/1
N2 - Reconstituted viral envelopes (RVEs) are formed by solubilizing intact virus in detergent and reassembling the envelope on removal of detergent. RVEs can be formed in the presence of agents that become encapsulated and can then be utilized in vitro and in vivo for drug delivery, cell destruction, transfer of membrane components, and as vectors for genetic engineering. The problems with biotechnological applications of RVEs and possible strategies for overcoming them are discussed in this article.
AB - Reconstituted viral envelopes (RVEs) are formed by solubilizing intact virus in detergent and reassembling the envelope on removal of detergent. RVEs can be formed in the presence of agents that become encapsulated and can then be utilized in vitro and in vivo for drug delivery, cell destruction, transfer of membrane components, and as vectors for genetic engineering. The problems with biotechnological applications of RVEs and possible strategies for overcoming them are discussed in this article.
UR - http://www.scopus.com/inward/record.url?scp=0026111221&partnerID=8YFLogxK
U2 - 10.1016/0167-7799(91)90013-8
DO - 10.1016/0167-7799(91)90013-8
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 1366950
AN - SCOPUS:0026111221
SN - 0167-7799
VL - 9
SP - 41
EP - 45
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 1
ER -