Reconstructing Denisovan Anatomy Using DNA Methylation Maps

David Gokhman; Nadav Mishol; Marc de Manuel; David de Juan; Jonathan Shuqrun; Eran Meshorer; Tomas Marques-Bonet; Yoel Rak; Liran Carmel

doi:10.1016/j.cell.2019.08.035

Reconstructing Denisovan Anatomy Using DNA Methylation Maps

David Gokhman^*
, Nadav Mishol
, Marc de Manuel
, David de Juan
, Jonathan Shuqrun
, Eran Meshorer
, Tomas Marques-Bonet
, Yoel Rak
, Liran Carmel

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

DNA methylation maps can be used to predict anatomical features in hominins and chimpanzees, allowing for reconstruction of a putative anatomical profile of the Denisovan, currently absent from the fossil record.

Original language	English
Pages (from-to)	180-192.e10
Journal	Cell
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.08.035
State	Published - 19 Sep 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

Denisova
Neanderthal
aDNA
disease
jaw
loss of function
methylome
paleoepigenetics
paleogenomics
phenotype

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10.1016/j.cell.2019.08.035

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abstract = "DNA methylation maps can be used to predict anatomical features in hominins and chimpanzees, allowing for reconstruction of a putative anatomical profile of the Denisovan, currently absent from the fossil record.",

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AU - de Manuel, Marc

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AU - Shuqrun, Jonathan

AU - Meshorer, Eran

AU - Marques-Bonet, Tomas

AU - Rak, Yoel

AU - Carmel, Liran

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KW - Denisova

KW - Neanderthal

KW - aDNA

KW - disease

KW - jaw

KW - loss of function

KW - methylome

KW - paleoepigenetics

KW - paleogenomics

KW - phenotype

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Reconstructing Denisovan Anatomy Using DNA Methylation Maps

Abstract

Bibliographical note

Keywords

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