Recurrent horizontal transfer of bacterial toxin genes to eukaryotes

Yehu Moran*, David Fredman, Pawel Szczesny, Marcin Grynberg, Ulrich Technau

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

In this work, we report likely recurrent horizontal (lateral) gene transfer events of genes encoding pore-forming toxins of the aerolysin family between species belonging to different kingdoms of life. Clustering based on pairwise similarity and phylogenetic analysis revealed several distinct aerolysin sequence groups, each containing proteins from multiple kingdoms of life. These results strongly support at least six independent transfer events between distantly related phyla in the evolutionary history of one protein family and discount selective retention of ancestral genes as a plausible explanation for this patchy phylogenetic distribution. We discuss the possible roles of these proteins and show evidence for a convergent new function in two extant species. We hypothesize that certain gene families are more likely to be maintained following horizontal gene transfer from commensal or pathogenic organism to its host if they 1) can function alone; and 2) are immediately beneficial for the ecology of the organism, as in the case of pore-forming toxins which can be utilized in multicellular organisms for defense and predation.

Original languageAmerican English
Pages (from-to)2223-2230
Number of pages8
JournalMolecular Biology and Evolution
Volume29
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

Keywords

  • aerolysin
  • horizontal gene transfer
  • pore-forming toxin

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