Recycling of synaptic vesicles in motor nerve endings separated from their target muscle fibers

M. Tal, S. Rotshenker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The application of the myotoxic local anesthetic Carbocaine to the cutaneous-pectoris muscle of the frog produced muscle fiber degeneration. The degenerating muscle fibers were phagocytozed by macrophages leaving behind structurally intact motor nerve endings in close apposition to the sheath of basal lamina that normally surrounds muscle fibers. These target deprived nerve terminals retained their ability to recycle synaptic vesicles in that they showed a low basal rate of spontaneous uptake of HRP that increased several fold upon nerve stimulation.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalBrain Research
Volume270
Issue number1
DOIs
StatePublished - 27 Jun 1983

Keywords

  • Carbocaine
  • HRP uptake
  • muscle fiber degeneration
  • synaptic vesicle recycling

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