Redistribution of cardiac output in anesthetized thermally dehydrated rats

1. 1. Cardiac output (CO) and its distribution were studied in dehydrated (37°C) anesthetized (Na thiopentone) rats prior to and following heat acclimation (at 34°C), using ⁵³Co 15 μm microspheres. 2. 2. In non-acclimated dehydrated rats, CO decreased while heart rate (HR) increased significantly. Following acclimation CO increased without any change in HR: during dehydration CO remained elevated together with a significant increase in HR. 3. 3. In non-acclimated rats at low dehydration blood perfusion to peripheral thermoregulatory areas increased while perfusion of splanchnic area decreased; at high dehydration level peripheral blood flow decreased whereas splanchnic blood flow was augmented. In acclimated dehydrated rats, CO distribution to thermoregulatory areas did not change while perfusion of the splanchnic area decreased. 4. 4. It is suggested that following acclimation, the increased CO contributes to maintenance of thermoregulatory peripheral blood flow; in non-acclimated rats severe dehydration leads to augmented blood flow in the permeable splanchnic vascular bed, increasing efflux of plasma protein and failure of plasma volume conservation.