Reduced Sensitivity of Lymphocyte Beta‐Adrenergic Receptors in Migraine

A. Kuritzky; Estelle R. Bennett; R. Hering; R. Ebstein

doi:10.1111/j.1526-4610.1993.hed33040198.x

Reduced Sensitivity of Lymphocyte Beta‐Adrenergic Receptors in Migraine

A. Kuritzky^*
, Estelle R. Bennett
, R. Hering
, R. Ebstein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

SYNOPSIS Cyclic AMP(CAMP) accumulation induced by isoproterenol (IP) and forskolin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8.20 + 1.08 Pmol/million cells) was significantly (P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forskolin‐induced CAMP did not differ in the two groups. These findings support the association of migraine and a reduced lymphocyte beta‐adrenergic receptor sensitivity. An alteration in lymphocyte beta‐adrenergic receptor may reflect similar changes in central beta‐adrenergic function and may be used as a probe to evaluate its activity.

Original language	English
Pages (from-to)	198-200
Number of pages	3
Journal	Headache
Volume	33
Issue number	4
DOIs	https://doi.org/10.1111/j.1526-4610.1993.hed33040198.x
State	Published - 1 Apr 1993
Externally published	Yes

Keywords

Autonomic nervous system
Beta‐Adrenergic receptor
Cyclic AMP
Lymphocytes
Migraine
forskolin

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10.1111/j.1526-4610.1993.hed33040198.x

Cite this

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title = "Reduced Sensitivity of Lymphocyte Beta‐Adrenergic Receptors in Migraine",

abstract = "SYNOPSIS Cyclic AMP(CAMP) accumulation induced by isoproterenol (IP) and forskolin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8.20 + 1.08 Pmol/million cells) was significantly (P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forskolin‐induced CAMP did not differ in the two groups. These findings support the association of migraine and a reduced lymphocyte beta‐adrenergic receptor sensitivity. An alteration in lymphocyte beta‐adrenergic receptor may reflect similar changes in central beta‐adrenergic function and may be used as a probe to evaluate its activity.",

keywords = "Autonomic nervous system, Beta‐Adrenergic receptor, Cyclic AMP, Lymphocytes, Migraine, forskolin",

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AU - Kuritzky, A.

AU - Bennett, Estelle R.

AU - Hering, R.

AU - Ebstein, R.

PY - 1993/4/1

Y1 - 1993/4/1

N2 - SYNOPSIS Cyclic AMP(CAMP) accumulation induced by isoproterenol (IP) and forskolin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8.20 + 1.08 Pmol/million cells) was significantly (P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forskolin‐induced CAMP did not differ in the two groups. These findings support the association of migraine and a reduced lymphocyte beta‐adrenergic receptor sensitivity. An alteration in lymphocyte beta‐adrenergic receptor may reflect similar changes in central beta‐adrenergic function and may be used as a probe to evaluate its activity.

AB - SYNOPSIS Cyclic AMP(CAMP) accumulation induced by isoproterenol (IP) and forskolin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8.20 + 1.08 Pmol/million cells) was significantly (P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forskolin‐induced CAMP did not differ in the two groups. These findings support the association of migraine and a reduced lymphocyte beta‐adrenergic receptor sensitivity. An alteration in lymphocyte beta‐adrenergic receptor may reflect similar changes in central beta‐adrenergic function and may be used as a probe to evaluate its activity.

KW - Autonomic nervous system

KW - Beta‐Adrenergic receptor

KW - Cyclic AMP

KW - Lymphocytes

KW - Migraine

KW - forskolin

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Reduced Sensitivity of Lymphocyte Beta‐Adrenergic Receptors in Migraine

Abstract

Keywords

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