TY - JOUR
T1 - Reduction by propranolol of raised urinary output of MHPG in hyperactive rats
AU - Speiser, Zipora
AU - Weinstock, Marta
PY - 1976/5
Y1 - 1976/5
N2 - Prolonged isolation of rats resulted in hyperactivity in the open field and a significant increase in 24 hr urinary excretion of MHPG (3-methoxy-4-hydroxyphenylglycol). Exploratory activity of group-housed rats in open field was not associated with raised MHPG excretion, compared with that of rats remaining in home cages. Exposure of group-housed rats to 4°C for 2 hr also increased urinary excretion of MHPG. Pretreatment of isolated rats with dl-, d-propranolol or practolol abolished hyperactivity of isolated rats and reduced MHPG output in these rats and in rats exposed to cold. dl-Propanolol did not reduce activity of grou-housed rats in open field or their urinary excretion of MHPG. It is suggested that propranolol may have a selective inhibitory effect on stress-induced increases in noradrenaline turnover.
AB - Prolonged isolation of rats resulted in hyperactivity in the open field and a significant increase in 24 hr urinary excretion of MHPG (3-methoxy-4-hydroxyphenylglycol). Exploratory activity of group-housed rats in open field was not associated with raised MHPG excretion, compared with that of rats remaining in home cages. Exposure of group-housed rats to 4°C for 2 hr also increased urinary excretion of MHPG. Pretreatment of isolated rats with dl-, d-propranolol or practolol abolished hyperactivity of isolated rats and reduced MHPG output in these rats and in rats exposed to cold. dl-Propanolol did not reduce activity of grou-housed rats in open field or their urinary excretion of MHPG. It is suggested that propranolol may have a selective inhibitory effect on stress-induced increases in noradrenaline turnover.
KW - Inhibition by dl-propranolol
KW - Isolation induced hyperactivity
KW - Raised MHPG excretion
KW - d-Propanolol Practolol
UR - http://www.scopus.com/inward/record.url?scp=0017116779&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(76)90193-3
DO - 10.1016/0091-3057(76)90193-3
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 951432
AN - SCOPUS:0017116779
SN - 0091-3057
VL - 4
SP - 531
EP - 534
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 5
ER -