Reduction in incidence of invasive fungal infection in patients receiving allogeneic stem cell transplantation using combined diagnostic-driven approach and itraconazole oral solution

Roie Tzadok, Michael Y. Shapira, Allon E. Moses, Reuven Or, Colin Block, Jacob Strahilevitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Invasive fungal infections are an important cause of morbidity and mortality after allogeneic haematopoietic stem cell transplantation. We evaluated, in our allogeneic stem cell transplant patients, the effect on the incidence of invasive fungal infection during neutropenia of a strategy combining a diagnostic-driven approach with chemoprophylaxis during higher risk periods of graft vs. host disease and prolonged neutropenia, using itraconazole oral solution with parenteral voriconazole bridging. One hundred and thirty patients admitted for allogeneic stem cell transplantation within two predefined 20month periods were included in the study. Data for all patients were collected prospectively. Implementation of the protocol resulted in the administration of more prophylactic antifungals to more patients. Following implementation, there was a non-significant decrease in the overall number of invasive fungal infections (IFI) [11 of 65 patients (17.2%) vs. 4 of 65 patients (6.2%, P=0.051)], as well as in the occurrence of invasive mould infections [8 of 65 patients (12.5%) vs. 2 of 65 patients (3.1%, P=0.054)]. Survival rates at three and 6months were not significantly affected. A combined diagnostic-driven approach and antifungal prophylaxis with oral itraconazole and an intravenous voriconazole bridging protocol, was associated with a reduced, albeit non-statistically significant, number of IFI in our medical centre.

Original languageAmerican English
Pages (from-to)694-698
Number of pages5
JournalMycoses
Volume58
Issue number12
DOIs
StatePublished - Dec 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Blackwell Verlag GmbH.

Keywords

  • Galactomannan
  • Invasive fungal infection
  • Itraconazole
  • Stem cell transplantation
  • Voriconazole

Fingerprint

Dive into the research topics of 'Reduction in incidence of invasive fungal infection in patients receiving allogeneic stem cell transplantation using combined diagnostic-driven approach and itraconazole oral solution'. Together they form a unique fingerprint.

Cite this