Reduction of cis,trans,cis-[PtCl2(OCOCH3) 2(NH3)2] by aqueous extracts of cancer cells

Alina Nemirovski; Yonit Kasherman; Yael Tzaraf; Dan Gibson

doi:10.1021/jm070740j

Reduction of cis,trans,cis-[PtCl₂(OCOCH₃) ₂(NH₃)₂] by aqueous extracts of cancer cells

Alina Nemirovski
, Yonit Kasherman
, Yael Tzaraf
, Dan Gibson^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Pt(IV) complexes must be reduced to kill cancer cells. While reduction rates correlate with reduction potentials, we wanted to check if the rates of reduction depend on the cell line used. The reduction of cis,trans,cis- [PtCl₂(OCOCH₃)₂(NH₃)₂] by extracts of three cell lines was measured, and the rates follow the order A2780cisR > A2780 > HT-29. The reduction is not carried out by the low molecular weight (MW) antioxidants but primarily by cellular components with MW > 3000.

Original language	English
Pages (from-to)	5554-5556
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	50
Issue number	23
DOIs	https://doi.org/10.1021/jm070740j
State	Published - 15 Nov 2007

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abstract = "Pt(IV) complexes must be reduced to kill cancer cells. While reduction rates correlate with reduction potentials, we wanted to check if the rates of reduction depend on the cell line used. The reduction of cis,trans,cis- [PtCl2(OCOCH3)2(NH3)2] by extracts of three cell lines was measured, and the rates follow the order A2780cisR > A2780 > HT-29. The reduction is not carried out by the low molecular weight (MW) antioxidants but primarily by cellular components with MW > 3000.",

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AU - Tzaraf, Yael

AU - Gibson, Dan

PY - 2007/11/15

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Reduction of cis,trans,cis-[PtCl₂(OCOCH₃) ₂(NH₃)₂] by aqueous extracts of cancer cells

Abstract

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