Reference values for lactic dehydrogenase activity and isoenzyme distribution in cerebrospinal fluid in neonates with fever but no evidence of cerebral disease

Moshe Nussinovitch*, Dario Prais, Benjamin Volovitz, Jacob Amir, Daniella Harel, Amos Nussinovitch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Levels of lactic dehydrogenase (LDH) in the cerebrospinal fluid (CSF) have been used to evaluate a variety of neurologic disorders. However, few studies have been performed on neonates. CSF samples were collected from 39 neonates, 19 aged 1-4 weeks and 20 aged 5-8 weeks with neonatal fever. Findings were compared to those in 15 infants mean age 10 ± 6.4 months with suspected nervous system disease and normal CSF findings. Mean total LDH activity in the CSF was significantly higher in the first month of life than in the second month of life and compared with the control group (p <0.001). The LDH isoenzyme pattern was also different, with lower values of LDH-1 than LDH-2 and -3 in the study groups. Differences were significant among all three groups for LDH-1 (p <0.001) and between the whole study group and the controls for LDH-2 and -3 (p <0.001). We propose reference values for total LDH activity and LDH isoenzyme distribution in the CSF of normal neonates.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalAmerican Journal of Perinatology
Volume19
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Cerebrospinal fluid
  • Lactic dehydrogenase (LDH)
  • Neonate

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