Regional Differences in S-Nitrosylation in the Cortex, Striatum, and Hippocampus of Juvenile Male Mice

Wajeha Hamoudi, Felix von Lendenfeld, Maryam Kartawy, Shira Mencer, Huda Suloh, Igor Khaliulin, Haitham Amal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Nitric oxide (NO) is a multifunctional neurotransmitter that plays a major role in neuronal and synaptic functions. S-nitrosylation (SNO), the NO-mediated protein posttransitional modification (PTM), is known to regulate physiological and pathological processes in the brain. However, the physiological role in different neuroanatomical brain regions has not been well investigated. To understand the role of SNO in the brain of juvenile WT mice, we used SNOTRAP technology. We mapped the SNO-proteome in three different neuroanatomical regions: cortex, striatum, and hippocampus. By conducting systems biology analysis, we found that the three brain regions share similar biological processes (BP) including biogenesis and developmental processes. Exclusive and different BP and molecular functions were found for each of the regions. Unraveling the BP and signaling mechanisms of SNO in the cortex, striatum, and hippocampus may help to understand the functional differences between the three regions under physiological conditions.

Original languageAmerican English
Pages (from-to)2383-2392
Number of pages10
JournalJournal of Molecular Neuroscience
Issue number11
StatePublished - Nov 2021

Bibliographical note

Funding Information:
We acknowledge the Satell Family Foundation for their generous support.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.


  • Brain
  • Cortex
  • Hippocampus
  • Nitric oxide
  • Posttranslational modification
  • Proteomics
  • S-nitrosylation
  • Striatum
  • System biology


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