Regions of active chromatin conformation in 'inactive' male meiotic sex chromosomes of the mouse

Carmelit Richler, Esther Uliel, Bat Sheva Kerem, Jacob Wahrman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The sensitivity to DNase I of the meiotic sex chromosomes of the male mouse was determined by in situ nick translation. At pachytene and diakinesis-metaphase I, six segments, four at the ends of the X and Y chromosomes and two at internal sites on the X chromosome, were found to be more sensitive than the other parts of these chromosomes. The sensitive segments presumably reflect an active or potentially active chromatin conformation which is maintained in the sex chromosomes despite the earlier reported, almost complete cessation of uridine incorporation. The distribution of regions which are sensitive to DNase I corresponds to that of early DNA replication bands. Active conformation patterns like those figured here, probably exist in the sex chromosomes of other mammals as well.

Original languageAmerican English
Pages (from-to)167-170
Number of pages4
JournalChromosoma
Volume95
Issue number3
DOIs
StatePublished - Jun 1987

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