Register-based information on thyroid diseases in Europe: lessons and results from the EUthyroid collaboration

Line Tang Møllehave*, Marie Holm Eliasen, Ieva Strēle, Allan Linneberg, Rodrigo Moreno-Reyes, Ludmila B. Ivanova, Zvonko Kusić, Iris Erlund, Till Ittermann, Endre V. Nagy, Ingibjorg Gunnarsdottir, Jonathan Eli Arbelle, Aaron Milton Troen, Valdis Pīrāgs, Lisbeth Dahl, Alicja Hubalewska-Dydejczyk, Malgorzata Trofimiuk-Müldner, João Jacome de Castro, Mafalda Marcelino, Simona GaberščekKatja Zaltel, Manuel Puig-Domingo, Lluis Vila, Sofia Manousou, Helena Filipsson Nyström, Michael Bruce Zimmermann, Karen R. Mullan, Jayne Valerie Woodside, Henry Völzke, Betina Heinsbæk Thuesen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: Registers of diagnoses and treatments exist in different forms in the European countries and are potential sources to answer important research questions. Prevalence and incidence of thyroid diseases are highly dependent on iodine intake and, thus, iodine deficiency disease prevention programs. We aimed to collect European register data on thyroid outcomes to compare the rates between countries/regions with different iodine status and prevention programs. Design: Register-based cross-sectional study. Methods: National register data on thyroid diagnoses and treatments were requested from 23 European countries/regions. The provided data were critically assessed for suitability for comparison between countries/regions. Sex-and age-standardized rates were calculated. Results: Register data on ≥1 thyroid diagnoses or treatments were available from 22 countries/regions. After critical assessment, data on medication, surgery, and cancer were found suitable for comparison between 9, 10, and 13 countries/regions, respectively. Higher rates of antithyroid medication and thyroid surgery for benign disease and lower rates of thyroid hormone therapy were found for countries with iodine insufficiency before approx. 2001, and no relationship was observed with recent iodine intake or prevention programs. Conclusions: The collation of register data on thyroid outcomes from European countries is impeded by a high degree of heterogeneity in the availability and quality of data between countries. Nevertheless, a relationship between historic iodine intake and rates of treatments for hyper-and hypothyroid disorders is indicated. This study illustrates both the challenges and the potential for the application of register data of thyroid outcomes across Europe.

Original languageAmerican English
Article numbere210525
JournalEndocrine Connections
Issue number3
StatePublished - Mar 2022

Bibliographical note

Publisher Copyright:
© 2022 The authors Published by Bioscientifica Ltd.


  • Europe
  • iodine
  • registries
  • thyroid diseases


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