Regulation of autophagy by amino acid availability in S. cerevisiae and mammalian cells

Hagai Abeliovich*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Autophagy is a catabolic membrane-trafficking process that occurs in all eukaryotic organisms analyzed to date. The study of autophagy has exploded over the last decade or so, branching into numerous aspects of cellular and organismal physiology. From basic functions in starvation and quality control, autophagy has expanded into innate immunity, aging, neurological diseases, redox regulation, and ciliogenesis, to name a few roles. In the present review, I would like to narrow the discussion to the more classical roles of autophagy in supporting viability under nutrient limitation. My aim is to provide a semblance of a historical overview, together with a concise, and perhaps subjective, mechanistic and functional analysis of the central questions in the autophagy field.

Original languageAmerican English
Pages (from-to)2165-2175
Number of pages11
JournalAmino Acids
Volume47
Issue number10
DOIs
StatePublished - 29 Oct 2015

Bibliographical note

Publisher Copyright:
© 2014 Springer-Verlag Wien.

Keywords

  • Amino acids
  • Autophagy
  • Macroautophagy
  • Microautophagy
  • Nitrogen starvation
  • Tor

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