Regulation of IgL Chain Recombination

Rena Levin-Klein; Yehudit Bergman

doi:10.1016/B978-0-12-374279-7.01008-0

Regulation of IgL Chain Recombination

Rena Levin-Klein^*, Yehudit Bergman

^*Corresponding author for this work

Department of Developmental Biology and Cancer Research

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

The immunoglobulin light chain loci (Igκ and Igλ) are recombined via V(D)J recombination at the pre-B cell stage during B cell differentiation. The recombination process is highly regulated on multiple levels to ensure proper timing and locus specificity. In this article, we focus on a number of mechanisms which contribute to the tight control of the rearrangement, focusing on the IgL locus, which is the primary IgL chain utilized in both mice and humans. We explain how regulation of locus accessibility, cellular signaling pathways, and transcription factor binding influence the recombination process. We also note regulation of the 'allelic exclusion' phenomenon, where only one B cell receptor is expressed in a single lymphocyte.

Original language	American English
Title of host publication	Development and Phylogeny of the Immune System
Publisher	Elsevier Inc.
Pages	71-77
Number of pages	7
Volume	1
ISBN (Print)	9780080921525
DOIs	https://doi.org/10.1016/B978-0-12-374279-7.01008-0
State	Published - 27 Apr 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd All rights reserved.

Keywords

Allelic exclusion
Asynchronous replication
B cell development
Chromatin accessibility
Cis-regulatory elements
DNA methylation
Hematopoietic stem cells
Igκ
Noncoding RNA
RAG complex
V(D)J recombination

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10.1016/B978-0-12-374279-7.01008-0

Cite this

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abstract = "The immunoglobulin light chain loci (Igκ and Igλ) are recombined via V(D)J recombination at the pre-B cell stage during B cell differentiation. The recombination process is highly regulated on multiple levels to ensure proper timing and locus specificity. In this article, we focus on a number of mechanisms which contribute to the tight control of the rearrangement, focusing on the IgL locus, which is the primary IgL chain utilized in both mice and humans. We explain how regulation of locus accessibility, cellular signaling pathways, and transcription factor binding influence the recombination process. We also note regulation of the 'allelic exclusion' phenomenon, where only one B cell receptor is expressed in a single lymphocyte.",

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AU - Bergman, Yehudit

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N2 - The immunoglobulin light chain loci (Igκ and Igλ) are recombined via V(D)J recombination at the pre-B cell stage during B cell differentiation. The recombination process is highly regulated on multiple levels to ensure proper timing and locus specificity. In this article, we focus on a number of mechanisms which contribute to the tight control of the rearrangement, focusing on the IgL locus, which is the primary IgL chain utilized in both mice and humans. We explain how regulation of locus accessibility, cellular signaling pathways, and transcription factor binding influence the recombination process. We also note regulation of the 'allelic exclusion' phenomenon, where only one B cell receptor is expressed in a single lymphocyte.

AB - The immunoglobulin light chain loci (Igκ and Igλ) are recombined via V(D)J recombination at the pre-B cell stage during B cell differentiation. The recombination process is highly regulated on multiple levels to ensure proper timing and locus specificity. In this article, we focus on a number of mechanisms which contribute to the tight control of the rearrangement, focusing on the IgL locus, which is the primary IgL chain utilized in both mice and humans. We explain how regulation of locus accessibility, cellular signaling pathways, and transcription factor binding influence the recombination process. We also note regulation of the 'allelic exclusion' phenomenon, where only one B cell receptor is expressed in a single lymphocyte.

KW - Allelic exclusion

KW - Asynchronous replication

KW - B cell development

KW - Chromatin accessibility

KW - Cis-regulatory elements

KW - DNA methylation

KW - Hematopoietic stem cells

KW - Igκ

KW - Noncoding RNA

KW - RAG complex

KW - V(D)J recombination

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SN - 9780080921525

VL - 1

SP - 71

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BT - Development and Phylogeny of the Immune System

PB - Elsevier Inc.

ER -

Regulation of IgL Chain Recombination

Abstract

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Keywords

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