Regulation of IgL Chain Recombination

Rena Levin-Klein*, Yehudit Bergman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


The immunoglobulin light chain loci (Igκ and Igλ) are recombined via V(D)J recombination at the pre-B cell stage during B cell differentiation. The recombination process is highly regulated on multiple levels to ensure proper timing and locus specificity. In this article, we focus on a number of mechanisms which contribute to the tight control of the rearrangement, focusing on the IgL locus, which is the primary IgL chain utilized in both mice and humans. We explain how regulation of locus accessibility, cellular signaling pathways, and transcription factor binding influence the recombination process. We also note regulation of the 'allelic exclusion' phenomenon, where only one B cell receptor is expressed in a single lymphocyte.

Original languageAmerican English
Title of host publicationDevelopment and Phylogeny of the Immune System
PublisherElsevier Inc.
Number of pages7
ISBN (Print)9780080921525
StatePublished - 27 Apr 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd All rights reserved.


  • Allelic exclusion
  • Asynchronous replication
  • B cell development
  • Chromatin accessibility
  • Cis-regulatory elements
  • DNA methylation
  • Hematopoietic stem cells
  • Igκ
  • Noncoding RNA
  • RAG complex
  • V(D)J recombination


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