Patterning the embryonic body relies on the complex integration of molecular information, normally involving a large number of signaling pathways. Activation of a specific pathway can determine the character of a specific region, cell or tissue, such as the embryonic organizer, notochord cells or neuronal tissue. In recent years, it has been demonstrated that the function of some signaling pathways amounts to negative regulation of other genes or factors, thereby constraining their effect both temporally and spatially. The timing and position of such regulators is crucial for the synchronization of developmental processes and the correct organization of the future organs and tissues of the body.
|Original language||American English|
|Title of host publication||The Vertebrate Organizer|
|Place of Publication||Berlin, Heidelberg|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||19|
|State||Published - 2004|