TY - JOUR
T1 - Regulation of the Human Interleukin-2/Interleukin-2 Receptor System
T2 - A Role for Immunosuppression
AU - Kaempfer, Raymond
PY - 1994/7
Y1 - 1994/7
N2 - The strength of the cellular immune response is regulated to a large extent by the amount of interleukin-2 (IL-2) produced in response to a stimulus. The ability of lymphocytes and other cells to respond to IL-2 depends upon the expression of cell surface IL-2 receptors. Formation of a high-affinity IL-2 receptor is regulated primarily through induction of its a subunit, IL-2Rα. Once formed, the IL-2Rα chain turns over rapidly, rendering expression of high-affinity IL-2 receptors during the immune response dependent upon continuous activity of the IL-2Rα gene. The induced expression of both human IL-2 and IL-2Rα chains is sensitive to cell-mediated suppression by CD8 cells; depletion of CD8 cells leads to extensive superinduction. This coupled suppression of IL-2 and IL-2Rα genes greatly increases the extent of control, and strongly limits the strength, of the signal transduced by this ligand/receptor system during an immune response.
AB - The strength of the cellular immune response is regulated to a large extent by the amount of interleukin-2 (IL-2) produced in response to a stimulus. The ability of lymphocytes and other cells to respond to IL-2 depends upon the expression of cell surface IL-2 receptors. Formation of a high-affinity IL-2 receptor is regulated primarily through induction of its a subunit, IL-2Rα. Once formed, the IL-2Rα chain turns over rapidly, rendering expression of high-affinity IL-2 receptors during the immune response dependent upon continuous activity of the IL-2Rα gene. The induced expression of both human IL-2 and IL-2Rα chains is sensitive to cell-mediated suppression by CD8 cells; depletion of CD8 cells leads to extensive superinduction. This coupled suppression of IL-2 and IL-2Rα genes greatly increases the extent of control, and strongly limits the strength, of the signal transduced by this ligand/receptor system during an immune response.
UR - http://www.scopus.com/inward/record.url?scp=0028473075&partnerID=8YFLogxK
U2 - 10.3181/00379727-206-43737
DO - 10.3181/00379727-206-43737
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C2 - 8016149
AN - SCOPUS:0028473075
SN - 0037-9727
VL - 206
SP - 176
EP - 180
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 3
ER -