Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma

Elad Jacoby; Michal Yalon; Moshe Leitner; Zvi R. Cohen; Yehudit Cohen; Tamar Fisher; Sarit Eder; Ninette Amariglio; Gideon Rechavi; Simona Cazacu; Cunli Xiang; Tom Mikkelsen; Chaya Brodie; Amos Toren

doi:10.3892/ol.2014.1829

Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma

Elad Jacoby^*, Michal Yalon, Moshe Leitner, Zvi R. Cohen, Yehudit Cohen, Tamar Fisher, Sarit Eder, Ninette Amariglio, Gideon Rechavi, Simona Cazacu, Cunli Xiang, Tom Mikkelsen, Chaya Brodie, Amos Toren

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.

Original language	English
Pages (from-to)	1209-1212
Number of pages	4
Journal	Oncology Letters
Volume	7
Issue number	4
DOIs	https://doi.org/10.3892/ol.2014.1829
State	Published - Apr 2014
Externally published	Yes

Keywords

Glioblastoma
Glioma pathogenesis-related protein 1
Methylation
Related to testes-specific vespid and pathogenesis protein-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ol.2014.1829

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title = "Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma",

abstract = "Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.",

keywords = "Glioblastoma, Glioma pathogenesis-related protein 1, Methylation, Related to testes-specific vespid and pathogenesis protein-1",

author = "Elad Jacoby and Michal Yalon and Moshe Leitner and Cohen, {Zvi R.} and Yehudit Cohen and Tamar Fisher and Sarit Eder and Ninette Amariglio and Gideon Rechavi and Simona Cazacu and Cunli Xiang and Tom Mikkelsen and Chaya Brodie and Amos Toren",

year = "2014",

month = apr,

doi = "10.3892/ol.2014.1829",

language = "אנגלית",

volume = "7",

pages = "1209--1212",

journal = "Oncology Letters",

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T1 - Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma

AU - Jacoby, Elad

AU - Yalon, Michal

AU - Leitner, Moshe

AU - Cohen, Zvi R.

AU - Cohen, Yehudit

AU - Fisher, Tamar

AU - Eder, Sarit

AU - Amariglio, Ninette

AU - Rechavi, Gideon

AU - Cazacu, Simona

AU - Xiang, Cunli

AU - Mikkelsen, Tom

AU - Brodie, Chaya

AU - Toren, Amos

PY - 2014/4

Y1 - 2014/4

N2 - Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.

AB - Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.

KW - Glioblastoma

KW - Glioma pathogenesis-related protein 1

KW - Methylation

KW - Related to testes-specific vespid and pathogenesis protein-1

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DO - 10.3892/ol.2014.1829

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SN - 1792-1074

VL - 7

SP - 1209

EP - 1212

JO - Oncology Letters

JF - Oncology Letters

IS - 4

ER -

Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma

Abstract

Keywords

UN SDGs

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