TY - JOUR
T1 - Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres
AU - Benita, Simon
AU - Babay, Dany
AU - Hoffman, Amnon
AU - Donbrow, Max
PY - 1988/3
Y1 - 1988/3
N2 - Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and kl values than in ensembles of microcapsules.
AB - Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and kl values than in ensembles of microcapsules.
KW - controlled release, first-order kinetics
KW - cumulative release profile
KW - indomethacin
KW - microspheres
KW - release, single microsphere
UR - http://www.scopus.com/inward/record.url?scp=0023929489&partnerID=8YFLogxK
U2 - 10.1023/A:1015917023949
DO - 10.1023/A:1015917023949
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C2 - 3244630
AN - SCOPUS:0023929489
SN - 0724-8741
VL - 5
SP - 178
EP - 182
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 3
ER -