Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres

Simon Benita*, Dany Babay, Amnon Hoffman, Max Donbrow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and kl values than in ensembles of microcapsules.

Original languageAmerican English
Pages (from-to)178-182
Number of pages5
JournalPharmaceutical Research
Volume5
Issue number3
DOIs
StatePublished - Mar 1988

Keywords

  • controlled release, first-order kinetics
  • cumulative release profile
  • indomethacin
  • microspheres
  • release, single microsphere

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