Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres

Simon Benita; Dany Babay; Amnon Hoffman; Max Donbrow

doi:10.1023/A:1015917023949

Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres

Simon Benita^*
, Dany Babay
, Amnon Hoffman
, Max Donbrow

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and k_l values than in ensembles of microcapsules.

Original language	English
Pages (from-to)	178-182
Number of pages	5
Journal	Pharmaceutical Research
Volume	5
Issue number	3
DOIs	https://doi.org/10.1023/A:1015917023949
State	Published - Mar 1988

Keywords

controlled release, first-order kinetics
cumulative release profile
indomethacin
microspheres
release, single microsphere

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abstract = "Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and kl values than in ensembles of microcapsules.",

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AB - Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and kl values than in ensembles of microcapsules.

KW - controlled release, first-order kinetics

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Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres

Abstract

Keywords

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