Relationship between calorie restriction and the biological clock: Lessons from long-lived transgenic mice

Oren Froy*, Nava Chapnik, Ruth Miskin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The master clock located in the brain regulates circadian rhythms in mammals. Similar clocks are found in peripheral tissues. Life span has been independently increased by reset circadian rhythms and caloric restriction (CR). The mechanisms by which CR extends life span are not well understood. We found that αMUPA transgenic mice that exhibit reduced eating and live longer show high amplitude, appropriately reset circadian rhythms in clock gene expression, and clock-controlled output systems, such as feeding time and body temperature. As CR resets circadian rhythms, and the circadian clock controls many physiological and biochemical systems, we suggest that the biological clock could be an important mediator of longevity in calorically restricted animals.

Original languageAmerican English
Pages (from-to)467-471
Number of pages5
JournalRejuvenation Research
Volume11
Issue number2
DOIs
StatePublished - 1 Apr 2008

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