Abstract
The effect of steroid structure on induction of chymotrypsinogen in embryonic chick pancreas was examined in vitro. In order of decreasing potency corntisol, corticosterone, and 21-deoxycortisol are classified as optimal inducers, whereas 11β-hydroxyprogesterone, 11-deoxycortisol, cortisone, 11-deoxycorticosterone and 17-α-hydroxyprogesterone are classified as suboptimal inducers. Progesterone was inactive. It is concluded thatthe relative importance of the steroid hydroxyl groups for activity is 11β>21⋟17αand that their effect is cumulative.
| Original language | English |
|---|---|
| Pages (from-to) | 475-478 |
| Number of pages | 4 |
| Journal | Endocrinology |
| Volume | 97 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1975 |
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